John Kelly may leave after clashing with the first lady Melania Trump

President Donald Trump's chief of staff John Kelly may be out of his job soon as a result of a conflict with first lady Melania Trump and other people in the White House, seven sources have told NBC News.

Nick Ayers, Vice President Mike Pence's chief of staff, is being considered for the job among other candidates, three of the sources told NBC.

Two White House officials told NBC that Melania Trump had told the president earlier in 2018 that Kelly had repeatedly turned down requests to promote some of her aides, even as Kelly's staff received promotions. Trump reportedly directed Kelly to approve the first lady's requests after learning of the disputes.

Melania Trump's spokeswoman Stephanie Grisham did not immediately respond to CNBC's request for comment on NBC's story.

That report followed a slew of news that Homeland Security Secretary Kirstjen Nielsen may be on her way out, too.

The secretary's potential forthcoming departure was reported a week after the midterm elections and days after the forced resignation of Attorney General Jeff Sessions.

But multiple outlets reported recently that Trump was planning a staff shakeup that would lead to both Nielsen and Kelly being removed.

"The Secretary is honored to lead the men and women of DHS and is committed to implementing the President's security-focused agenda to protect Americans from all threats and will continue to do so," DHS press secretary Tyler Houlton said in a statement Tuesday.

Nielsen had served in the Trump administration under chief of staff John Kelly before being confirmed to the Cabinet-level position in December.